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EPZ015666 (GSK3235025)

EPZ015666 (GSK3235025)

Item no.	V0390-500mg
Manufacturer	InvivoChem LLC
CASRN	1616391-65-1
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0390CAS #:1616391-65-1Purity >=98% Description: EPZ015666 (GSK-3235025; EPZ-015866), an analog of EPZ-015866, is a potent, selective and orally bioavailable inhibitor of PRMT5 (protein arginine methyltransferase) with antineoplastic activity. It inhibits the enzymatic activity of PRMT5 with Ki of 5-22 nM in biochemical assays, and displays > 20, 000-fold selectivity for PRMT5 over other PMTs. Description References: Nat Chem Biol. 2015 Jun; 11(6):432-7. References: Related CAS: 1616391-87-7 (EPZ015866)
Molecular Weight (MW)	383.44
Formula	C20H25N5O3
CAS No.	1616391-65-1;
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (156.5 mM)
	Water: < 1 mg/mL
	Ethanol: 48 mg/mL (125.2 mM)
Solubility (In vivo)	2% DMSO+30% PEG 300+ddH2O: 5 mg/mL
Synonyms	GSK-3235025; GSK 3235025; GSK3235025; EPZ-015666; EPZ 015666; EPZ015666. Chemical Name: (S)-N-(3-(3, 4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide InChi Key: ZKXZLIFRWWKZRY-KRWDZBQOSA-N InChi Code: InChI=1S/C20H25N5O3/c26-17(10-25-6-5-14-3-1-2-4-15(14)9-25)8-21-20(27)18-7-19(23-13-22-18)24-16-11-28-12-16/h1-4, 7, 13, 16-17, 26H, 5-6, 8-12H2, (H, 21, 27)(H, 22, 23, 24)/t17-/m0/s1 SMILES Code: O=C(C1=NC=NC(NC2COC2)=C1)NC[CH](O)CN3CC4=C(C=CC=C4)CC3

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Amount: 500 mg

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Delivery expected until 9/4/2025

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