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MI-2 (Menin-MLL Inhibitor)

MI-2 (Menin-MLL Inhibitor)

Item no.	V0396-25mg
Manufacturer	InvivoChem LLC
CASRN	1271738-62-5
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0396CAS #:1271738-62-5Purity >=98% Description: MI-2 (MI2, Menin-MLL Inhibitor) is a novel, potent and selective inhibitor of menin-MLL interaction with antineoplastic activity. It inhibits menin-MLL interaction with an IC50 of 446 nM. MI-2 acts by binding to the wild-type menin but doesn't bind M278K and Y323K menin mutants. In HEK293 cells transfected with Flag-MLL-AF9, MI-2 effectively inhibited the menin-MLL-AF9 interaction without affecting the expression level of menin and MLL-AF9. Description: References: Nat Chem Biol. 2012 Jan 29; 8(3):277-84. References:
Molecular Weight (MW)	375.55
Formula	C18H25N5S2
CAS No.	1271738-62-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 75 mg/mL (199.7 mM)
	Water:< 1 mg/mL
	Ethanol: NA
Other info	Chemical Name: 4-[4-(5, 5-dimethyl-4H-1, 3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2, 3-d]pyrimidine InChi Key: SRQYLNYQAPCPIR-UHFFFAOYSA-N InChi Code: InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2, 3)25-17/h10, 12H, 4-9, 11H2, 1-3H3 SMILES Code: CCCC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1
Synonyms	MI2 ; Menin-MLL inhibitor 2; MI 2 ; Menin MLL inhibitor 2; MI-2 ; Menin-MLL inhibitor-2;

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Amount: 25 mg

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Delivery expected until 10/2/2025

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