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EPZ004777

EPZ004777

Item no.	V0401-100mg
Manufacturer	InvivoChem LLC
CASRN	1338466-77-5
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0401CAS #:1338466-77-5 (free)Purity >=98% Description: EPZ004777 (EPZ-004777) is a potent and selective inhibitor of DOT1 Like Histone Lysine Methyltransferase (DOT1L) inhibitor with antineoplastic activity. It inhibits DOT1L with an IC50 of 0.4 nM in a cell-free assay. It shows potent in vitro antiproliferative activity and high in vivo antitumor efficacy. Exposure of leukemic cells to EPZ 004777 laed to selective killing of cells bearing MLL gene translocation, with little effect on non-MLL-translocated cells. In addition, EPZ004777 extended the survival of mice bearing a MLL xenograft model. Description References: Leukemia. 2013 Apr; 27(4):813-22; Cancer Cell. 2011 Jul 12; 20(1):53-65. References: Related CAS: 1380316-03-9 (HCl)
Molecular Weight (MW)	539.67
Formula	C28H41N7O4
CAS No.	1338466-77-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (185.3 mM)
	Water:< 1 mg/mL
	Ethanol: 100 mg/mL (185.3 mM)
Other info	Chemical Name: 1-(3-((((2R, 3S, 4R, 5R)-5-(4-amino-7H-pyrrolo[2, 3-d]pyrimidin-7-yl)-3, 4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea InChi Key: WXRGFPHDRFQODR-ICLZECGLSA-N InChi Code: InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3, 4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11, 14, 16-17, 21-23, 26, 36-37H, 6, 12-13, 15H2, 1-5H3, (H2, 29, 31, 32)(H2, 30, 33, 38)/t21-, 22-, 23-, 26-/m1/s1 SMILES Code: O=C(NC1=CC=C(C(C)(C)C)C=C1)NCCCN(C[CH]2O[CH](N3C=CC4=C(N)N=CN=C43)[CH](O)[CH]2O)C(C)C
Synonyms	EPZ 004777; EPZ-004777; EPZ004777

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 12/4/2025

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