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ATN-161 TFA

ATN-161 TFA

Item no.	V0434-500mg
Manufacturer	InvivoChem LLC
CASRN	904763-27-5
Amount	500 mg
Quantity options	100 mg 10 mg 1 mg 250 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0434CAS #:904763-27-5Purity >=98% Description: ATN-161 TFA, the trifluoroacetic acid salt of ATN161, is a novel and potent small peptide inhibitor of the integrin alpha5beta1 with potential anticancer activity. It inhibits the angiogenesis and growth of liver metastases in a murine model. ATN-161 acts by interacting with the N-terminus of the beta1-domain of integrin alpha5beta1, which may lock this integrin in an inactive conformation. Integrin alpha5beta1 is expressed on activated endothelial cells and plays a critical role in tumor angiogenesis. Therefore, ATN-161 has potential anticancer activities.The combination of ATN-161 with 5-fluorouracil (5-FU) chemotherapy has shown enhanced antineoplastic effect. References: Int J Cancer. 2003 Apr 20; 104(4):496-503. Related CAS: 262438-43-7 (free base)
Molecular Weight (MW)	711.67
Formula	C25H36F3N9O10S
CAS No.	904763-27-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-2-((R)-2-((S)-2-((S)-2-((S)-1-acetylpyrrolidine-2-carboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-hydroxypropanamido)-3-mercaptopropanamido)succinamide trifluoroacetic acid
Synonyms	AcPHSCNNH2; ATN161; ATN 161; ATN-161
SMILES Cod	O=C(N)[CH](NC([CH](NC([CH](NC([CH](NC([CH]1N(C(C)=O)CCC1)=O)CC2=CN= CN2)=O)CO)=O)CS)=O)CC(N)=O.O=C(O)C(F)(F)F

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Amount: 500 mg

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