SL-327

Description: SL327 (SL-327) is a novel, potent and selective inhibitor for MEK1/2 with the ability to cross blood brain barrier and block fear conditioning. It inhibits MEK1/2 with IC50s of 0.18 uM/ 0.22uM, and shows little/no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII. SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. SL327 had no affect on acquisition, expression, or extinction of EtOH-induced CPP in mice despite causing significant reduction of pERK levels in multiple brain regions.

References: J Biol Chem. 2000 Nov 24; 275(47):37086-92; J Neurosci. 2000 Dec 1; 20(23):8701-9.

SL 327; SL-327; SL327

Chemical Name: (E)-3-amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile

InChi Key: JLOXTZFYJNCPIS-SQFISAMPSA-N

InChi Code: InChI=1S/C16H12F3N3S/c17-16(18, 19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H, 21-22H2/b15-13-

SMILES Code: N#C/C(C1=CC=CC=C1C(F)(F)F)=C(N)/SC2=CC=C(N)C=C2