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TCS JNK 5a

TCS JNK 5a

Item no.	V0473-500mg
Manufacturer	InvivoChem LLC
CASRN	312917-14-9
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0473CAS #:312917-14-9Purity >=98% Description: TCS JNK 5a (also known as JNK Inhibitor IX; TCS JNK-5a) is a novel, highly selective and potent JNK (c-Jun N-terminal Kinase) inhibitor with potential antineoplastic activity. It inhibits JNK2/3 with pIC50 values of 6.5 and 6.7, respectively. It has no/little effects against EGFR, ErbB2, VegFr2, Src, Tie-2, Alk5, c-Fms, CDK-2, GSK3beta and PLK1 with pIC50 values of < 5.0. Exposure of human Jurkat T cells to SC-202671 targeting JNK2 and JNK3, caused apoptotic DNA fragmentation along with G2/M arrest, phosphorylation of Bcl-2, Mcl-1, and Bim, deltapsim loss, and activation of Bak and caspase cascade. Description: References: Bioorg Med Chem Lett. 2007 Mar 1; 17(5):1296-301. References:
Molecular Weight (MW)	332.42
Formula	C20H16N2OS
CAS No.	312917-14-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO:20 mg/mL (60.2 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Other info	Chemical Name: N-(3-cyano-4, 5, 6, 7-tetrahydrobenzo[b]thiophen-2-yl)-1-naphthamide InChi Key: WQGDQGAFSDMBLA-UHFFFAOYSA-N InChi Code: InChI=1S/C20H16N2OS/c21-12-17-15-9-3-4-11-18(15)24-20(17)22-19(23)16-10-5-7-13-6-1-2-8-14(13)16/h1-2, 5-8, 10H, 3-4, 9, 11H2, (H, 22, 23) SMILES Code: O=C(C1=CC=CC2=CC=CC=C21)NC(S3)=C(C#N)C4=C3CCCC4
Synonyms	SC202671, JNK Inhibitor-IX, TCS-JNK-5a, TCS JNK 5a, JNK Inhibitor IX, SC-202671, SC 202671,

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Amount: 500 mg

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Delivery expected until 9/4/2025

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