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Brivanib (BMS-540215)

Brivanib (BMS-540215)

Item no.	V0506-100mg
Manufacturer	InvivoChem LLC
CASRN	649735-46-6
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0506CAS #:649735-46-6Purity >=98% Description: Brivanib (formerly BMS-540215; BMS540215) is a novel, investigational, oral and ATP-competitive inhibitor of VEGFR2 with potential anticancer activity. It inhibits VEGFR2 with an IC50 of 25 nM, and shows moderate potency against VEGFR-1 and FGFR-1, but > 240-fold against PDGFR-beta. It exhibits excellent anti-proliferative activity in vitro and high in vivo antitumor efficacy in H3396 xenografts in athymic mice. Description:H3396 xenografts in athymic mice. References: J Med Chem. 2006 Apr 6; 49(7):2143-6; Clin Cancer Res. 2008 Oct 1; 14(19):6146-53. References: Related CAS: 649735-63-7 (alaninate); 649735-46-6
Molecular Weight (MW)	370.38
Formula	C19H19FN4O3
CAS No.	649735-46-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 3 mg/mL (8.1 mM)
SMILES	C[CH](O)COC1=CN2N=CN=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)C2=C1C
Synonyms	Brivanib; BMS-540215; BMS 540215; BMS540215 Chemical Name: (R)-1-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2, 1-f][1, 2, 4]triazin-6-yl)oxy)propan-2-ol InChi Key: WCWUXEGQKLTGDX-LLVKDONJSA-N InChi Code: InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7, 9, 11, 23, 25H, 8H2, 1-3H3/t11-/m1/s1 SMILES Code: C[CH](O)COC1=CN2N=CN=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)C2=C1C

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Amount: 100 mg

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Delivery expected until 10/2/2025

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