OSI-930

Description: OSI-930 is an orally bioavailable, potent and selective inhibitor of multi-kinase (Kit, KDR and CSF-1R) with potential antineoplastic activity. It inhibits Kit, KDR and CSF-1R with IC50s of 80 nM, 9 nM and 15 nM, respectively; It is also potent against Flt-1, c-Raf and Lck but shows low activity against PDGFRalpha/beta, Flt-3 and Abl. OSI-930 is a thiophene-derived tyrosine kinase inhibitor that shows potent anti-proliferative activity in vitro and high in vivo antitumor efficacy.

References: Cancer Res. 2006 Jan 15; 66(2):1015-24; Drug Metab Dispos. 2011 Feb; 39(2):345-50.

Synonym: OSI-930; OSI 930; OSI930.

Chemical Name: 3-((quinolin-4-ylmethyl)amino)-N-(4-(trifluoromethoxy)phenyl)thiophene-2-carboxamide

InChi Key: FGTCROZDHDSNIO-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H16F3N3O2S/c23-22(24, 25)30-16-7-5-15(6-8-16)28-21(29)20-19(10-12-31-20)27-13-14-9-11-26-18-4-2-1-3-17(14)18/h1-12, 27H, 13H2, (H, 28, 29)

SMILES Code: O=C(C1=C(NCC2=CC=NC3=CC=CC=C23)C=CS1)NC4=CC=C(OC(F)(F)F)C=C4