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ZM 306416 (CB676475)

ZM 306416 (CB676475)

Item no.	V0525-1g
Manufacturer	InvivoChem LLC
CASRN	690206-97-4
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0525CAS #:690206-97-4Purity >=98% Description: ZM-306416 (CB-676475) is a novel and potent tyrosine kinase inhibitor of VEGFR1 (vascular endothelial growth factor receptor 1) with potential antineoplastic activity. It inhibits VEGFR1 with an IC50 of 0.33 uM, but also inhibits EGFR with an IC50 of< 10 nM. Description: References: J Biomol Screen. 2012 Aug; 17(7):885-99; Mol Cell Endocrinol. 2012 Apr 4; 351(2):199-207; J Cell Physiol. 2012 May; 227(5):1992-2002. References:
Molecular Weight (MW)	333.74
Formula	C16H13ClFN3O2
CAS No.	690206-97-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 67 mg/mL (200.8 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
SMILES Code	COC1=CC2=NC=NC(NC3=CC=C(Cl)C=C3F)=C2C=C1OC
Synonyms	ZM 306416; ZM-306416; CB 676475; CB676475; CB-676475; ZM306416; Chemical Name: 4-[(4'-Chloro-2'-fluoro)phenylamino]-6, 7-dimethoxyquinazoline InChi Key: YHUIUSRCUKUUQA-UHFFFAOYSA-N InChi Code: InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H, 1-2H3, (H, 19, 20, 21) SMILES Code: COC1=CC2=NC=NC(NC3=CC=C(Cl)C=C3F)=C2C=C1OC

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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