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PD168393 (PD-168393)

PD168393 (PD-168393)

Item no.	V0547-50mg
Manufacturer	InvivoChem LLC
CASRN	194423-15-9
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0547CAS #:194423-15-9Purity >=98% Description: PD168393 (PD-168393) is covalent / irreversible, cell-permeable and ATP-competitive EGFR inhibitor with potential anticancer activity. It inhibits EGFR with an IC50 of 0.70 nM. PD 168393 acts by irreversibly alkylating the Cys-773 residue of EGFR and shows no activity against insulin, PDGFR, FGFR and PKC. Description: References: Proc Natl Acad Sci U S A. 1998; 95: 12022–12027; Proc Natl Acad Sci U S A. 2006; 103:9773-8. References:
Molecular Weight (MW)	369.22
Formula	C17H13BrN4O
CAS No.	194423-15-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (200.4 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL
Synonyms	PD 168393; PD-168393; PD168393; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline InChi Key: HTUBKQUPEREOGA-UHFFFAOYSA-N InChi Code: InChI=1S/C17H13BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h2-10H, 1H2, (H, 21, 23)(H, 19, 20, 22) SMILES Code: C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O

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Amount: 50 mg

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