PF-00562271 besylate

Description: PF-00562271 besylate (also called PF562271 or PF-562271 Besylate), the benzenesulfonate salt form of PF-00562271, is an ATP-competitive and orally bioavailable inhibitor of FAK (focal adhesion kinase) and Pyk2 catalytic activity with potential antitumor activity. It inhibits FAK and Pyk2 with IC50s of 1.5 and 14 nmol/L, respectively. It demonstrates high in vivo antitumor efficacy against multiple human xenograft models.

References: Cancer Res. 2008 Mar 15; 68(6):1935-44; Cancer Biol Ther. 2010 Jul 1; 10(1):38-43.

Related CAS: 939791-41-0 (HCl); 717907-75-0 (free base); 939791-39-6 (mesylate); 939791-40-9 (tosylate); 939791-38-5 (besylate)

Chemical Name: N-methyl-N-(3-(((2-((2-oxoindolin-5-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)methyl)pyridin-2-yl)methanesulfonamide benzenesulfonate

InChi Key: LKLWTLXTOVZFAE-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2, 33)34)19-12(4-3-7-25-19)10-26-18-15(21(22, 23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16; 7-10(8, 9)6-4-2-1-3-5-6/h3-8, 11H, 9-10H2, 1-2H3, (H, 29, 32)(H2, 26, 27, 28, 30); 1-5H, (H, 7, 8, 9)

SMILES Code: CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O