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Radotinib (IY 5511; Supect)

Radotinib (IY 5511; Supect)

Item no.	V0673-500mg
Manufacturer	InvivoChem LLC
CASRN	926037-48-1
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0673CAS #:926037-48-1Purity >=98% Description: Radotinib (formerly IY-5511; IY5511; trade name Supect) is a novel, potent, selective, orally bioavailable, and 2nd generation BCR-ABL1 tyrosine kinase inhibitor with potential antineoplastic activity. It inhibits BCR-ABL1 with an IC50 of 34 nM. It was developed by Ilyang Pharmaceutical in S. Korea and has the potential for the treatment of Chronic Myeloid Leukemia. Description: References: Haematologica. 2014 Jul; 99(7):1191-6; PLoS One. 2015 Jun 12; 10(6):e0129853. References: Related CAS #: 926037-48-1 (free base) 926037-85-6 (2HCl)
Molecular Weight (MW)	530.50
Formula	C27H21F3N8O
CAS No.	926037-48-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (188.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide InChi Key: DUPWHXBITIZIKZ-UHFFFAOYSA-N InChi Code: InChI=1S/C27H21F3N8O/c1-16-3-4-18(9-23(16)37-26-33-6-5-22(36-26)24-13-31-7-8-32-24)25(39)35-20-10-19(27(28, 29)30)11-21(12-20)38-14-17(2)34-15-38/h3-15H, 1-2H3, (H, 35, 39)(H, 33, 36, 37) SMILES Code: O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=NC=CN=C5)=N4)=C3
Synonyms	IY-5511; IY5511; Radotinib; IY-5511 HCl; IY 5511; IY5511 HCl; trade name Supect.

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Amount: 500 mg

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Delivery expected until 9/4/2025

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