GNF-5

Item no.	V0674-100mg
Manufacturer	InvivoChem LLC
CASRN	778277-15-9
Amount	100 mg
Quantity options	1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0674CAS #:778277-15-9Purity >=98% Description: GNF-5 (GNF 5; GNF5), a GNF-2 analog with better pharmacokinetic profiles, is a potent, selective and allosteric/non-ATP competitive Bcr-Abl inhibitor with potential anticancer activity. It inhibits Bcr-Abl (wild-type Abl) with an IC50 of 220 nM. It exhibits excellent in vivo anticancer efficacy in Ba/F3.p210 xenograft mouse model. Description: Ba/F3.p210 xenograft mouse model References: Nature. 2010 Jan 28; 463(7280):501-6; J Med Chem. 2010 Oct 14; 53(19):6934-46. References:
Molecular Weight (MW)	418.37
Formula	C20H17F3N4O3
CAS No.	778277-15-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (198.4 mM)
	Water: < 1 mg/mL
	Ethanol: 20 mg/mL warmed (47.8 mM)
Other info	Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide InChi Key: IIQUYGWWHIHOCF-UHFFFAOYSA-N InChi Code: InChI=1S/C20H17F3N4O3/c21-20(22, 23)30-16-6-4-15(5-7-16)27-18-11-17(25-12-26-18)13-2-1-3-14(10-13)19(29)24-8-9-28/h1-7, 10-12, 28H, 8-9H2, (H, 24, 29)(H, 25, 26, 27) SMILES Code: O=C(NCCO)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
Synonyms	GNF 5; GNF5; GNF-5;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 1 days

Compare

Add to wishlist

Get an offer