MG-132

Item no.	V0685-250mg
Manufacturer	InvivoChem LLC
CASRN	133407-82-6
Amount	250 mg
Quantity options	100 mg 10 mg 1 g 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V0685CAS #:133407-82-6Purity >=98% Description: MG-132, a peptide aldehyde, is a novel, specific, potent, reversible, and cell-permeable inhibitor of proteasome with IC50 of 100 nM in a cell-free assay, and also inhibits calpain with IC50 of 1.2 uM. References: J Biochem. 1996; 119(3):572-6; Am J Pathol. 2003; 163(4):1663-75; BMC Musculoskelet Disord. 2011; 12:185. Related CAS: 133407-82-6 (MG-132); 1211877-36-9 (R-isomer) : 133407-82-6 (MG-132) Publications Citing Use of InvivoChem MG-132: Eur J Med Chem. 2020 May 5; 199:112377 Publications Citing Use of InvivoChem MG-132:
Molecular Weight (MW)	475.62
Formula	C26H41N3O5
CAS No.	133407-82-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 95 mg/mL (199.7 mM)
	Water: < 1 mg/mL
	Ethanol: 95 mg/mL (199.7 mM)
Solubility (In vivo)	4% DMSO+30% PEG 300+20% propylene glycol+ddH2O: 2 mg/mL
Synonyms	MG-132; MG132; MG 132; benzyl ((S)-4-methyl-1-(((S)-4-methyl-1-(((S)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)amino)-1-oxopentan-2-yl)carbamate InChi Key: TZYWCYJVHRLUCT-VABKMULXSA-N InChi Code: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11, 15, 17-19, 21-23H, 12-14, 16H2, 1-6H3, (H, 27, 31)(H, 28, 32)(H, 29, 33)/t21-, 22-, 23-/m0/s1 SMILES Code: O=C(OCC1=CC=CC=C1)N[CH](CC(C)C)C(N[CH](CC(C)C)C(N[CH](CC(C)C)C=O)=O)=O

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Amount: 250 mg

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Delivery expected until 12/4/2025

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