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Cathepsin Inhibitor 1

Cathepsin Inhibitor 1

Item no.	V0699-25mg
Manufacturer	InvivoChem LLC
CASRN	225120-65-0
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0699CAS #:225120-65-0Purity >=98% Description: Cathepsin Inhibitor 1 (CTS-IN-1) is a novel and potent inhibitor of Cathepsin (L, L2, S, K, B) with the potential to be used in the treatment of osteoarthritis. It inhibits Cathepsin (L, L2, S, K, B) with pIC50 values of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. The lysosomal cysteine protease2 Cathepsin L (CatL) is found to be a potential target for intervention in treatment of osteoarthritis. After secreted into the extracellular matrix, CatL can degrade proteoglycans such as aggrecan4 and type II collagen, which are the major components of articular cartilage. References: Bioorg Med Chem Lett. 2009 Aug 1; 19(15):4280-3.
Molecular Weight (MW)	401.89
Formula	C20H24ClN5O2
CAS No.	225120-65-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 80 mg/mL (199.1 mM)
	Water: < 1 mg/mL
	Ethanol: 50 mg/mL (124.4 mM)
Other info	Chemical Name: (S)-3-(tert-butyl)-N-(3-(3-chlorophenyl)-1-((cyanomethyl)amino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide InChi Key: MZRVIHRERYCHBL-HNNXBMFYSA-N InChi Code: InChI=1S/C20H24ClN5O2/c1-20(2, 3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7, 10, 12, 15H, 9, 11H2, 1-4H3, (H, 23, 27)(H, 24, 28)/t15-/m0/s1 SMILES Code: ClC1=CC=CC(C[CH](C(NCC#N)=O)NC(C2=CC(C(C)(C)C)=NN2C)=O)=C1
Synonyms	Cathepsin-Inhibitor-1; CTS-IN-1; Cathepsin Inhibitor 1; CTS IN 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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Delivery expected until 11/6/2025

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