Loxistatin Acid (E-64C; NSC694279; EP475)

Description: Loxistatin Acid (formerly also known as E-64C; NSC-694279; EP-475), an analog of E-64, is a novel, potent, irreversible and membrane-permeable cysteine protease inhibitor with important biological activity. E-64-c has proved to be substantially more reactive than E-64 with cathepsins B and L. Cathepsins B and H from human liver and rat cathepsin L were used to measure the rate constants of inhibition of E-64-c, which indicated the rate constants of inactivation of cathepsins B, H and L were 298000, 2018, 206000 M-1 s-1 , respectively.

References: Biochem Biophys Res Commun. 1989 Jan 31; 158(2):432-5; J Neurosci Res. 2003 Nov 1; 74(3):393-405.