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Alvelestat (AZD-9668; MPH-966)

Alvelestat (AZD-9668; MPH-966)

Item no.	V0713-250mg
Manufacturer	InvivoChem LLC
CASRN	848141-11-7
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0713CAS #:848141-11-7 Purity >=98% Description: Alvelestat (formerly also known as MPH966; AZD9668) is a novel, potent, orally bioavailable, and highly selective inhibitor of neutrophil elastase (NE) with potential anti-inflammatory activity. It inhibits neutrophil elastase with an IC50 and Ki of 12 nM and 9.4 nM, it is at least 600-fold more selective over other serine proteases. References: J Pharmacol Exp Ther. 2011 Oct; 339(1):313-20. Related CAS: 1240425-05-1 (Alvelestat tosylate salt)
Molecular Weight (MW)	545.53
Formula	C25H22F3N5O4S
CAS No.	848141-11-7 (Alvelestat);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (183.3 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
SMILES	O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4
Synonyms	Alvelestat; AZD 9668; MPH966; MPH 966; AZD9668; AZD-9668; MPH-966 Chemical Name: 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1, 2-dihydropyridine-3-carboxamide InChi Key: QNQZWEGMKJBHEM-UHFFFAOYSA-N InChi Code: InChI=1S/C25H22F3N5O4S/c1-15-20(22-9-10-31-32(22)2)12-21(23(34)30-13-17-7-8-19(14-29-17)38(3, 36)37)24(35)33(15)18-6-4-5-16(11-18)25(26, 27)28/h4-12, 14H, 13H2, 1-3H3, (H, 30, 34)

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Amount: 250 mg

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Delivery expected until 9/4/2025

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