ML130 (Nodinitib-1)

Description: ML130 (also known as Nodinitib-1; ML-130; CID1088438; CID-1088438) is a novel, potent and selective inhibitor of NOD1 (nucleotide-binding oligomerization domain containing 1) with potential anti-inflammatory activity. It inhibits NOD1 with an IC50 of 0.56 uM. It acts by inhibiting NF-kappaB activation and exhibiting 36-fold selectivity for NOD1 over NOD2. ML130 selectively inhibits NOD1-dependent activation of NF-kappaB and MAPK signaling and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability. In ex vivo dendritic cell culture, 15 uM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1beta, IL-6, and TNF-alpha.

References: Chem Biol. 2011 Jul 29; 18(7):825-32; ACS Med Chem Lett. 2011 Oct 13; 2(10):780-785

Chemical Name: 1-(4-methylphenyl)sulfonylbenzimidazol-2-amine

InChi Key: SRFABRWQVPCPRG-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18, 19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H, 1H3, (H2, 15, 16)

SMILES Code: NC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=OInChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18, 19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H, 1H3, (H2, 15, 16)