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BMS-202

BMS-202

Item no.	V0770-50mg
Manufacturer	InvivoChem LLC
CASRN	1675203-84-5
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0770CAS #:1675203-84-5Purity >=98% Description: PD1-PDL1 inhibitor 2 (also known as BMS-202, BMS 202, BMS202), is a novel and potent inhibitor of the PD-1 (Programmed death- 1)/PD-Ll (Programmed death-ligand 1) protein/protein interaction with potential antineoplastic activity. It was reported in patent WO/2015034820 A1, compound example 202. Homogenous time-resolved fluorescence (HTRF) assay showed that BMS-202 has good in vitro activity with IC50 values of less than 50 nM in the cell-free assay. However, no in vivo data has been reported for this compound. Structural basis for blocking the PD-1/PD-L1 interaction by small molecule BMS-202 that binds to and induces dimerization of PD-L1. Description: References: J Med Chem. 2017 Jul 13; 60(13):5857-5867; WO/2015034820 A1 References: Publications Citing Use of InvivoChem BMS-202: 1) J Med Chem. 2020 Dec 24; 63(24):15946-15959. doi: 10.1021/acs.jmedchem.0c01684; 2) J Med Chem. 2020 Aug 13; 63(15):8338-8358. doi: 10.1021/acs.jmedchem.0c00574.
Molecular Weight (MW)	419.52
Formula	C25H29N3O3
CAS No.	1675203-84-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 83 mg/mL (197.8 mM)
	Water: < 1 mg/mL (slightly soluble or insoluble)
	Ethanol: 83 mg/mL (197.8 mM)
SMILES Code	CC(NCCNCC1=CC=C(OCC2=C(C)C(C3=CC=CC=C3)=CC=C2)N=C1OC)=O
Chemical Name	N-(2-(((2-methoxy-6-((2-methyl-[1, 1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide
Synonym	BMS-202; PD-1/PD-L1 inhibitor 2; BMS 202; BMS202;

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Amount: 50 mg

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Delivery expected until 10/2/2025

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