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Roflumilast (BY217; B 9302107; BYK-20869; Daxas; Daliresp)

Roflumilast (BY217; B 9302107; BYK-20869; Daxas; Daliresp)

Item no.	V0777-500mg
Manufacturer	InvivoChem LLC
CASRN	162401-32-3
Amount	500 mg
Quantity options	100 mg 10 mg 1 g 250 mg 2 g 50 mg 5 g
Category	Cardiovascular Research Atherosclerosis Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0777CAS #:162401-32-3; Purity >=98% Description: Roflumilast (BY-217; APTA-2217; B 9302-107; BYK20869; Daxas; Daliresp) is a novel, highly potent, selective, and long-acting inhibitor of phosphodiesterase 4/PDE4 with potential anti-inflammatory activity. It inhibits PDE4 with IC50s of 0.2-4.3 nM in a cell-free assay. It has anti-inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, and chronic obstructive pulmonary disease (COPD). In vitro studies show that roflumilast inhibits the production of inflammatory mediators in a variety of human immune cells, suggesting a role for reducing COPD-related inflammation. Description: References: Pulm Pharmacol Ther. 2010 Aug; 23(4):235-56; J Pharmacol Exp Ther. 2001 Apr; 297(1):267-79. References: Related CAS: 292135-78-5 (Roflumilast N-oxide); 1391052-76-8 (Roflumilast Impurity E)
Molecular Weight (MW)	403.21
Formula	C17H14Cl2F2N2O3
CAS No.	162401-32-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 81 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol: 15 mg/mL (37.2 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	Daliresp; BY217; BY-217; B 9302-107; BYK 20869; B-9302-107; APTA 2217, B9302-107, BY 217, BYK-20869; BYK20869; Daxas;

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Amount: 500 mg

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