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Abiraterone Acetate (Zytiga; formerly CB-7598; CB7598; CB 7598)

Abiraterone Acetate (Zytiga; formerly CB-7598; CB7598; CB 7598)

Item no.	V0801-10g
Manufacturer	InvivoChem LLC
CASRN	154229-18-2
Amount	10 g
Quantity options	100 mg 1 g 25 g 2 g 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0801CAS #:154229-18-2Purity >=98% Description: Abiraterone Acetate (brand name Zytiga; formerly CB-7598; CB7598; CB 7598), the 3-acetylated and prodrug form of Abiraterone, is an irreversible and steroidal cytochrome CYP17 inhibitor with potential antitumor activity. It inhibits CYP17 with an IC50 of 72 nM in a cell-free assay. Steroid CYP17/17alpha-monooxygenase is an enzyme involved in testosterone synthesis. Abiraterone acetate has been approved by the FDA in April 2011 for metastatic castration-resistantprostate cancer. Description: References: J Clin Oncol. 2008 Oct 1; 26(28):4563-71; J Med Chem. 2010 Aug 12; 53(15):5749-58. References: Related CAS #: 154229-19-3 (Abiraterone); 154229-18-2 (Abiraterone Acetate);
Molecular Weight (MW)	391.55
Formula	C26H33NO2
CAS No.	154229-18-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 28 mg/mL (71.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	5% DMSO+95% Corn oil: 30mg/mL
Synonyms	Abiraterone Acetate; CB7630; CB 7630 ; CB-7630; trade name: Zytiga Chemical Name: [(3S, 10R, 13S)-10, 13-dimethyl-17-pyridin-3-yl-2, 3, 4, 7, 8, 9, 11, 12, 14, 15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate InChi Key: UVIQSJCZCSLXRZ-HMMZIKKISA-N InChi Code: InChI=1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23, 3)13-11-24(21)25/h4-6, 8, 14, 16, 20-21, 23-24H, 7, 9-13, 15H2, 1-3H3/t20-, 21?, 23?, 24?, 25-, 26+/m0/s1 SMILES Code: CC(O[CH]1CC[C]2(C)C3CC[C]4(C)C(C5=CC=CN=C5)=CCC4C3CC=C2C1)=O

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Amount: 10 g

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