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Description: Pioglitazone (U-72107A; AD-4833; Actos; AD4833, U-72107E) is approved andthiazolidinedione-based anti-diabetic drug which acts as a selective PPAR? (Peroxisome proliferator-activated receptor gamma) agonistwith hypoglycemic activity. It inhibits PPAR? with EC50s of 0.93 and0.99 uM for human and mouse PPARgamma, respectively.
References: Basic Clin Pharmacol Toxicol. 2006 Jul; 99(1):44-51; Circulation. 2002 Dec 10; 106(24):3126-32.
Related CAS #: 111025-46-8 (free); 112529-15-4 (HCl);
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