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AGI-5198

AGI-5198

Item no.	V0855-500mg
Manufacturer	InvivoChem LLC
CASRN	1355326-35-0
Amount	500 mg
Quantity options	100 mg 1 g 250 mg 25 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0855CAS #:1355326-35-0Purity >=98% Description: AGI-5198 (also know as IDH-C35; IDHC35; AGI-5198; AGI 5198) is a novel, highly potent and selective inhibitor of IDH1 (isocitrate dehydrogenase 1) R132H/R132C mutants with potential anticancer activity. It inhibits IDH1 R132H/R132C with IC50 of 0.07 uM/0.16 uM, respectively. AGI-5198 demonstrates significant in vivo antitumor efficacy in IDH1 mutant glioma xenografts. Description:IDH1 mutant glioma xenografts. References: Science. 2013 May 3; 340(6132):626-30. References:
Molecular Weight (MW)	462.56
Formula	C27H31FN4O2
CAS No.	1355326-35-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 24 mg/mL (51.9 mM)
	Water: < 1 mg/mL
	Ethanol: 14 mg/mL (30.3 mM)
Solubility (In vivo)	0.5% methylcellulose+0.2% Tween 80: 30mg/mL
Synonyms	IDH C35; AGI5198; IDH-C35; IDHC35; AGI-5198; AGI 5198; Chemical Name: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-(o-tolyl)acetamide InChi Key: FNYGWXSATBUBER-UHFFFAOYSA-N InChi Code: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10, 13-17, 22, 26H, 3-5, 11-12, 18H2, 1-2H3, (H, 30, 34) SMILES Code: O=C(NC1CCCCC1)C(N(C2=CC=CC(F)=C2)C(CN3C=CN=C3C)=O)C4=CC=CC=C4C

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Amount: 500 mg

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Delivery expected until 9/4/2025

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