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KW-2478

KW-2478

Item no.	V0889-10mg
Manufacturer	InvivoChem LLC
CASRN	819812-04-9
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0889CAS #:819812-04-9Purity >=98% Description: KW-2478 (KW 2478; KW2478) is a nonansamycin inhibitor of HSP90 (Heat Shock Protein 90) with potential antitumor activity. It inhibits HSP90 with an IC50 of 3.8 nM. It demonstrates significant in vivo antitumor efficacy in NCI-H929 tumor-bearing SCID mice. Description:CI-H929 tumor-bearing SCID mice. References: Clin Cancer Res. 2010 May 15; 16(10):2792-802. References: Related CAS #: 819812-04-9 (free base); 819812-18-5 (HCl);
Molecular Weight (MW)	574.66
Formula	C30H42N2O9
CAS No.	819812-04-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 115 mg/mL (200.1 mM)
	Water: < 1 mg/mL
	Ethanol: 3 mg/mL (5.2 mM)
Solubility (In vivo)	30% propylene glycol, 5% Tween 80, 65% D5W: 10mg/mL
Synonyms	Synonym: KW-2478; KW2478; KW 2478. Chemical Name: 2-(2-ethyl-3, 5-dihydroxy-6-(3-methoxy-4-(2-morpholinoethoxy)benzoyl)phenyl)-N, N-bis(2-methoxyethyl)acetamide InChi Key: VFUXSYAXEKYYMB-UHFFFAOYSA-N InChi Code: InChI=1S/C30H42N2O9/c1-5-22-23(19-28(35)32(11-13-37-2)12-14-38-3)29(25(34)20-24(22)33)30(36)21-6-7-26(27(18-21)39-4)41-17-10-31-8-15-40-16-9-31/h6-7, 18, 20, 33-34H, 5, 8-17, 19H2, 1-4H3 SMILES Code: O=C(N(CCOC)CCOC)CC1=C(C(C2=CC=C(OCCN3CCOCC3)C(OC)=C2)=O)C(O)=CC(O)=C1CC

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Amount: 10 mg

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Delivery expected until 9/4/2025

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