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Tolcapone

Tolcapone

Item no.	V0919-100mg
Manufacturer	InvivoChem LLC
CASRN	134308-13-7
Amount	100 mg
Quantity options	10 mg 1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0919CAS #:134308-13-7Purity >=98% Description: Tolcapone (Ro 40-7592; SOM-0226; Ro-407592; Tasmar), an approved anti-Parkinson's disease (PD) agent, is a reversible and orally bioavailable inhibitor of catechol-O-methyl transferase (COMT) with potential anti-PD effects. It inhibits COMT with Ki of 30 NM. COMTcatalyses a relatively minor pathway of dopamine metabolism, therefore the action of dopamine can be enhanced by tolcapone. Tolcapone is used in combination with levodopa for the treatment of Parkinson's disease (PD). Description: References: Adv Neurol. 1990; 53:497-503; Br J Pharmacol. 1996 Feb; 117(3):516-520. References:
Molecular Weight (MW)	273.24
Formula	C14H11NO5
CAS No.	134308-13-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 55 mg/mL (201.3 mM)
	Water: < 1 mg/mL
	Ethanol: 55 mg/mL (201.3 mM)
Other info	Chemical Name: (3, 4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone InChi Key: MIQPIUSUKVNLNT-UHFFFAOYSA-N InChi Code: InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7, 16, 18H, 1H3 SMILES Code: O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)C2=CC=C(C)C=C2
Synonyms	SOM0226; Ro 40 7592; Tolcapone, Tasmar, Ro 40-7592; Ro-40-7592; SOM-0226; SOM 0226;

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Amount: 100 mg

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