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FTI 277 HCl

FTI 277 HCl

Item no.	V0923-250mg
Manufacturer	InvivoChem LLC
CASRN	180977-34-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0923CAS #:180977-34-8 Purity >=98% Description: FTI 277 HCl (FTI-277; FTI277), the HCl salt of FTI 277, is a peptide mimetic of the COOH-terminal Cys-Val-Ile-Met of K-Ras4B which is a novel, potent and selective farnesyltransferase (FTase) inhibitor with antiviral activity. It inhibits FTase with an IC50 of 500 pM. It shows > 100-fold selectivity for FTase over the closely related GGTase I. FTI-277 is a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling.FTI-277 inhibits the processing of both oncogenic and normal Ras. FTI-277 was extremely potent (IC50 = 100 nM) at inhibiting H-Ras, but not the geranylgeranylated Rap1A processing in whole cells. Description: References: J Biol Chem. 1995 Nov 10; 270(45):26802-6; Cancer Res. 1996 Apr 15; 56(8):1727-30; J Clin Invest. 2003 Aug; 112(3):407-14. References: Related CAS: 1217447-06-7 (TFA); 170006-73-2 (free base);
Molecular Weight (MW)	484.07
Formula	C22H30ClN3O3S2
CAS No.	180977-34-8(HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 96 mg/mL (198.3 mM)
	Water: 17 mg/mL (35.1 mM)
	Ethanol: 14 mg/mL (28.9 mM)
Other info	Chemical Name: methyl (5-(((R)-2-amino-3-mercaptopropyl)amino)-[1, 1'-biphenyl]-2-carbonyl)-L-methioninate hydrochloride InChi Key: PIAFFJUUNXEDEW-PXPMWPIZSA-N InChi Code: InChI=1S/C22H29N3O3S2.ClH/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15; /h3-9, 12, 16, 20, 24, 29H, 10-11, 13-14, 23H2, 1-2H3, (H, 25, 26); 1H/t16-, 20+; /m1./s1 SMILES Code: CSCC[CH](C(OC)=O)NC(C1=CC=C(NC[CH](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl
Synonyms	FTI-227 HCl; FTI-277; FTI 277; FTI-227 hydrochloride, FTI277;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 10/2/2025

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