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Isotretinoin

Isotretinoin

Item no.	V0933-1g
Manufacturer	InvivoChem LLC
CASRN	4759-48-2
Amount	1 g
Quantity options	100 mg 250 mg 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0933CAS #:4759-48-2Purity >=98% Description: Isotretinoin (Accutane; Myorisan; Zenatane; 13-cis retinoic acid) is a topically used medication approved for the treatment of severe cystic acne. It was originally developed to be used as a chemotherapeutic drug for the treatment of various cancers such as brain cancer, pancreatic cancer etc. Isotretinoin directly interferes with the development of cranial neural crest cells. Isotretinoin selectively affects neural crest cells by decreasing their cell-substratum adhesion. Isotretinoin (500 ng/mL) and its main metabolite in the human, 4-oxo-isotretinoin, induce malformations similar to those seen in vivo. Description: References: J Craniofac Genet Dev Biol. 1986; 6(3):211-22; Dev Biol. 1987 Sep; 123(1):276-81; Pharmacol Biochem Behav. 2008 Dec; 91(2):243-51. References:
Molecular Weight (MW)	300.44
Formula	C20H28O2
CAS No.	4759-48-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (199.7 mM)
	Water: < 1 mg/mL
	Ethanol: 1 mg/mL (3.32 mM)
Other info	Chemical Name: (2Z, 4E, 6E, 8E)-3, 7-dimethyl-9-(2, 6, 6-trimethylcyclohex-1-en-1-yl)nona-2, 4, 6, 8-tetraenoic acid InChi Key: SHGAZHPCJJPHSC-XFYACQKRSA-N InChi Code: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18, 4)5/h6, 8-9, 11-12, 14H, 7, 10, 13H2, 1-5H3, (H, 21, 22)/b9-6+, 12-11+, 15-8+, 16-14- SMILES Code: CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C/C(O)=O
Synonyms	13-cis retinoic acid; Accutane; Isotretinoin; Myorisan; Zenatane

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