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Tamibarotene

Tamibarotene

Item no.	V0946-5g
Manufacturer	InvivoChem LLC
CASRN	94497-51-5
Amount	5 g
Quantity options	100 mg 1 g 250 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0946CAS #:94497-51-5Purity >=98% Description: Tamibarotene (formerly SY-1425; SY1425; Am 80; Retinobenzoic acid, Amnoid, AMNOLAKE) is a novel, potent, orally bioavailable, and synthetic retinoic acid receptor (RAR) agonist with potential anticancer activity against AML-acute promyelocytic leukaemia. It has high specificity for RARalpha and RARbeta over RARgamma. Tamibarotene is developed to overcome all-trans retinoic acid (ATRA) resistance. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Description: References: Leukemia. 2005 Jun; 19(6):901-9; J Leukoc Biol. 2011 Aug; 90(2):235-47; Biol Pharm Bull. 2009 Jul; 32(7):1307-9. References:
Molecular Weight (MW)	351.44
Formula	C22H25NO3
CAS No.	94497-51-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 70 mg/mL (199.2 mM)
	Water: < 1 mg/mL
	Ethanol: 70 mg/mL (199.2 mM)
SMILES Code	O=C(O)C1=CC=C(C(NC2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1
Synonyms	SY-1425; Am80, SY 1425; Am 80, SY1425; Retinobenzoic acid, Amnoid, AMNOLAKE, Am-80;

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