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Edoxaban tosylate monohydrate (DU-176b)

Edoxaban tosylate monohydrate (DU-176b)

Item no.	V0950-50mg
Manufacturer	InvivoChem LLC
CASRN	1229194-11-9
Amount	50 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0950CAS #:1229194-11-9Purity >=98% Description: Edoxaban tosylate monohydrate (DU-176b; DU-176; trade name Lixiana), the tosylate salt of edoxaban which is a marketed anticoagulant drug, is a potent, selective, orally bioavailable and direct factor Xa inhibitor with potential anti-coagulant activity. It inhibits Factor Xa with a Ki of 0.561 nM, and exhibits > 10 000-fold selectivity over thrombin and FIXa. Edoxaban was developed by Daiichi Sankyo and was approved in July 2011 in Japan for prevention of venous thromboembolisms (VTE) following lower-limb orthopedic surgery. It was also approved by the FDA in January 2015 for the prevention of stroke and non–central-nervous-system systemic embolism. Description: References: J Thromb Haemost. 2008 Sep; 6(9):1542-9. References: Related CAS #: 480449-71-6 (tosylate); 480448-29-1 (HCl); 1229194-11-9 (tosylate hydrate); 480449-70-5 (free base)
Molecular Weight (MW)	738.27
Formula	C24H30ClN7O4S.C7H8O3S.H2O
CAS No.	1229194-11-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (135.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES Code	O=C(NC1=NC=C(Cl)C=C1)C(N[CH]2[CH](NC(C(S3)=NC4=C3CN(C)CC4)=O)C[CH](C(N(C)C)=O)CC2)=O.CC5=CC=C(S(=O)(O)=O)C=C5.[H]O[H]
Synonyms	DU176b; DU 176b; Edoxaban; DU-176; DU 176; DU-176b; DU176; Edoxaban tosylate monohydrate, trade name Lixiana.

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Amount: 50 mg

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