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Sorafenib (Bay 43-9006)

Sorafenib (Bay 43-9006)

Item no.	V1010-10g
Manufacturer	InvivoChem LLC
CASRN	284461-73-0
Amount	10 g
Quantity options	1 g 25 g 2 g 500 mg 50 g 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1010CAS #:284461-73-0 Purity >=98% Description: Sorafenib (BAY549085; BAY-549085; BAY439006; BAY-439006; Nexavar; SFN), an approved anticancer drug, is a potent and orally bioavailable multikinase inhibitor with potential anticancer activity. It inhibits multiple kinases including Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM in enzymatic assays, respectively. Sorafenib was approved by FDA in 2005 for the treatment of advanced renal cancer. Description: References: Cancer Res. 2004 Oct 1; 64(19):7099-109; Cancer Res. 2006 Dec 15; 66(24):11851-8. References: Related CAS#: 475207-59-1 (tosylate)
Molecular Weight (MW)	464.82
Formula	C21H16ClF3N4O3
CAS No.	284461-73-0 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (135.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide InChi Key: MLDQJTXFUGDVEO-UHFFFAOYSA-N InChi Code: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23, 24)25/h2-11H, 1H3, (H, 26, 30)(H2, 28, 29, 31) SMILES Code: O=C(C1=NC=CC(OC2=CC=C(C=C2)NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=C1)NC
Synonyms	BAY 43-9006; BAY-439-006; BAY439006; BAY-439006; BAY 439006; BAY 549085; trade name: Nexavar; SFN.

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Amount: 10 g

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Delivery expected until 12/4/2025

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