GW5074

Item no.	V1011-50mg
Manufacturer	InvivoChem LLC
CASRN	220904-83-6
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1011CAS #:220904-83-6Purity >=98% Description: GW5074 (GW-5074; GW 5074) is a novel, potent and selective c-Raf inhibitor with potential neuroprotective activity. It inhibits c-Raf with an IC50 of 9 nM and exhibits no activities against other kinases such as JNK1/2/3, MKK6/7, CDK1/2, MEK1, c-Src, VEGFR2, p38 MAP, or c-Fms. GW-5074 is able to prevent neurodegeneration and improve behavioral outcome in an animal model of Huntington's disease. GW 5074 has therapeutic potential for treating neurodegenerative pathologies in humans. Description: References: 1 Chin PC, et al. J Neurochem, 2004, 90(3), 595-608.; 2 Yue X, et al. Eur J Pharmacol, 2006, 540(1-3), 57-59. References:
Molecular Weight (MW)	520.94
Formula	C15H8Br2INO2
CAS No.	220904-83-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO:104 mg/mL (199.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% propylene glycol, 5% Tween 80, 65% D5W: 30mg/mL
Synonyms	GW5074; GW 5074; GW-5074; 3-(3, 5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1, 3-dihydro-indol-2-one

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50 mg

available

Delivery expected until 11/6/2025

Express Delivery: Save 20 days

Compare

Add to wishlist

Get an offer