Acotiamide hydrochloride trihydrate (YM443; Z338)

Description: Acotiamide hydrochloride trihydrate (YM-443; Z-338) is a potent, orally bioactive and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia. It is approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.Acotiamide monohydrochloride trihydrate enhances acetylcholine released by enteric neurons through muscarinic receptor antagonism and acetylcholinesterase (AChE) inhibition, thereby enhancing gastric emptying and gastric accommodation. It acts as an acetylcholinesterase inhibitor.

References:

1. Nowlan ML, et al. Acotiamide: first global approval. Drugs. 2013 Aug; 73(12):1377-83.

2. Attia KAM, et al. Spectrofluorimetric determination of acotiamide hydrochloride trihydrate in the presence of its oxidative degradation product. Luminescence. 2018 Jun; 33(4):806-811.

3. Efficacy of acotiamide in combination with esomeprazole for functional dyspepsia refractory to proton-pump inhibitor monotherapy. Tohoku J Exp Med. 2014; 234(3):237-40.

Related CAS #: 773092-05-0 (HCl hydrate) 185106-16-5 (free base) 185104-11-4 (HCl)