Ibuprofen (Advil; Motrin; Brufen)

Description: Ibuprofen (Dolgesic; Advil, Motrin, Nurofen, Brufen among others), a potent anti-inflammatory drug of the NSAID class, is an inhibitor of COX-1 and COX-2 enzymes with IC50s of 13 uM and 370 uM, respectively. Ibuprofen is an isobutylphenylpropanoic acid-based, and nonsteroidal anti-inflammatory drug (NSAID) used for treating pain, fever, and inflammation. This includes painful menstrual periods, migraines, and rheumatoid arthritis. In HCT-116 p53wt or HCT-116 p53-/-colon carcinoma cell lines, S- and R-ibuprofen induced apoptosis and blocked cell cycle is in part dependent on p53. The anti-proliferative effects were significantly higher in the p53wt cell line than in the p53-deficient cells.

References: J Nat Prod. 1998 Jan; 61(1):2-7; Arteriosclerosis. 1983 Jul-Aug; 3(4):383-8.

Related CAS#: 57469-77-9 (lysine); 57469-82-6 (ariginine); 51146-56-6 (Dexibuprofen, also known as S-ibuoprofen free acid); 1113403-10-4 (Dexibuprofen lysine); 141505-32-0 (Dexibuprofen lysine hydrate); 64622-41-9 (Ibuprofen diethylaminoethyl ester); 64622-45-3 (Ibuprofen piconol); 51146-57-7 (R-Ibuprofen); 121839-78-9 ((-)-Ibuprofenamide); 121662-14-4 (Ibuprofen D3); 51146-55-5 (2-Hydroxy Ibuprofen); 1329643-44-8 (S)-(+)-Ibuprofen D3; 15935-54-3 (Ibuprofen carboxylic acid);