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Rofecoxib (MK 966)

Rofecoxib (MK 966)

Item no.	V1045-1g
Manufacturer	InvivoChem LLC
CASRN	162011-90-7
Amount	1 g
Quantity options	100 mg 10 g 250 mg 2 g 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V1045CAS #:162011-90-7Purity >=98% Description: Rofecoxib (formerly MK-0966; MK0966; MK-966; MK966; Vioxx; Ceoxx; Ceeoxx.), an NSAID drug, is a potent and selective COX-2 inhibitor with potential anti-inflammatory activity. It inhibits COX-2 with an IC50 of 18 NM. Rofecoxib belongs to the nonsteroidal anti-inflammatory drug (NSAID) class and has now been withdrawn from the market due to safety concerns. Rofecoxib exhibits anti-inflammatory, analgesic, and antipyretic activities in animal models. The mechanism of action of rofecoxib is believed to be due to inhibition of prostaglandin synthesis, via inhibition of cyclooxygenase-2 (COX-2). Description: References: J Pharmacol Exp Ther. 1999 Aug; 290(2):551-60; J Gastroenterol Hepatol. 2007 Jun; 22(6):877-84. References:
Molecular Weight (MW)	314.36
Formula	C17H14O4S
CAS No.	162011-90-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (200.4 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL
Synonyms	MK-0966; MK0966; MK0966; MK966; MK966; MK 966; MK 0966; Trade name: Vioxx; Ceoxx; Ceeoxx.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 9/4/2025

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