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Lumiracoxib (CGS 35189; COX 189)

Lumiracoxib (CGS 35189; COX 189)

Item no.	V1068-1g
Manufacturer	InvivoChem LLC
CASRN	220991-20-8
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1068CAS #:220991-20-8Purity >=98% Description: Lumiracoxib (formerly CGS-35189; COX-189; trade name Prexige), a non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 enzyme inhibitor with potential anti-inflammatory activity. It inhibits COX-2 with an IC50 and a Ki of 0.14 uM and 0.06 uM, and exhibits 515-fold selectivity for COX-2 over COX-1. Lumiracoxib has anti-inflammatory, analgesic and antipyretic activities comparable with diclofenac, the reference NSAID, but with much improved gastrointestinal safety. Lumiracoxib has an IC50 of 0.14 um in COX-2-expressing dermal fibroblasts, but caused no inhibition of COX-1 at concentrations up to 30 um. Description: References: Br J Pharmacol. 2005 Feb; 144(4):538-50. References:
Molecular Weight (MW)	293.72
Formula	C15H13ClFNO2
CAS No.	220991-20-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 59 mg/mL (200.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: 2-(2-((2-chloro-6-fluorophenyl)amino)-5-methylphenyl)acetic acid InChi Key: KHPKQFYUPIUARC-UHFFFAOYSA-N InChi Code: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7, 18H, 8H2, 1H3, (H, 19, 20) SMILES Code: O=C(O)CC1=CC(C)=CC=C1NC2=C(F)C=CC=C2Cl
Synonyms	Lumiracoxib; COX-189; CGS-35189; CGS 35189; COX189; CGS35189; COX 189; trade name: Prexige.

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