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VU 0364439

VU 0364439

Item no.	V1085-10mg
Manufacturer	InvivoChem LLC
CASRN	1246086-78-1
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1085CAS #:1246086-78-1Purity >=98% Description: VU 0364439 (VU0364439; VU-0364439) is a mGlu4 (metabotropic glutamate receptor 4) positive allosteric modulator (PAM) with important biological activity. It inhibits mGlu4 with an EC50 value of 19.8 nM. Due to the fact that VU 0364439 possessed less favorable pharmacokinetic properties, thus it can not be used as an in vivo tool, but VU 0364439 might inform the mGlu4 community with more in vitro tool compounds. The activation of the mGlu4 receptor, either with an orthosteric agonist or a positive allosteric modulator (PAM), provides impactful interventions in diseases such as Parkinson's disease, anxiety, and pain. mGlu4 PAMs may have several advantages over mGlu4 agonists for a number of reasons. Description: References: Bioorg Med Chem Lett. 2010 Sep 1; 20(17):5175-8; J Med Chem. 2011 Jul 28; 54(14):5070-81. References:
Molecular Weight (MW)	422.29
Formula	C18H13Cl2N3O3S
CAS No.	1246086-78-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 85 mg/mL (201.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES Code	O=C(C1=NC=CC=C1)NC2=CC=C(S(=O)(NC3=CC=CC=C3Cl)=O)C(Cl)=C2
Synonyms	VU0364439, VU-0364439, VU 0364439

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 mg

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Delivery expected until 9/4/2025

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