VU 0364770

Description: VU 0364770 (VU-0364770, VU0364770) is a potent positive allosteric modulator (PAM) of mGlu4 (metabotropic glutamate receptor 4) with anti-parkinsonian-like activity. It inhibits mGlu with an EC50 of 1.1 uM for human mGlu4. It exhibits little activity at 68 other receptors such as other mGlu subtypes. Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGlu?), including N-phenyl-7-(hydroxyimino) cyclopropabchromen-1a-carboxamide, can produce anti-parkinsonian-like effects in preclinical models of PD. VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

References: J Pharmacol Exp Ther. 2012 Feb; 340(2):404-21.