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Brimonidine Tartrate (UK 14304; AGN190342)

Brimonidine Tartrate (UK 14304; AGN190342)

Item no.	V1105-1g
Manufacturer	InvivoChem LLC
CASRN	70359-46-5
Amount	1 g
Quantity options	100 mg 250 mg 2 g 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1105CAS #:70359-46-5Purity >=98% Description: Brimonidine Tartrate (AGN-190342; UK14304; UK-14304; Alphagan), the tartrate salt of Brimonidine, is a highly potent and selective alpha-adrenergic receptor agonist with anti-hypertensive effects. It activates the alpha2A adrenoreceptor with an EC50 of 0.45 nM. Brimonidine was approved to treat open-angle glaucoma or ocular hypertension. Brimonidine reduces the progressive loss of ganglion cells to 26% and 15% at doses of 0.5 mg/kg and 1 mg/kg, respectively. Brimonidine administration initiates 10 days after IOP elevation prevents any further loss of ganglion cells. Brimonidine attenuates the increase in immunoreactivity of GFAP in ocular hypertensive retinas. Description: References: Invest Ophthalmol Vis Sci. 2001 Nov; 42(12):2849-55; Brain Res. 2001 Sep 21; 913(2):133-9. References: Related CAS#: 59803-98-4 (free base); 70359-46-5 (tartrate)
Molecular Weight (MW)	442.22
Formula	C15H16BrN5O6
CAS No.	70359-46-5 (tartrate salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 88 mg/mL (199 mM)
	Water: < 1 mg/mL
	Ethanol: 75 mg/mL (169.6 mM)
SMILES	C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.C(C(C(=O)O)O)(C(=O)O)O
Synonyms	AGN 190342; UK 14304; UK14304; Alphagan; AGN-190342; AGN190342; UK 14, 304-18; UK 14, 304; UK-14304; UK-14, 304-18; UK-14, 308

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