Terazosin HCl dihydrate

Description: Terazosin HCl (Hytrin; A-45975; A45975), the hydrochloride salt ofterazosin, is a potent and selective alpha1-adrenoceptor antagonist with antihypertensive effects. It has been used for treatment of BPH- benign prostatic hyperplasia (symptoms of an enlarged prostate). Terazosin induces cytotoxicity in PC-3 and human benign prostatic cells with an IC50 of more than 100 uM. Terazosin also effectively inhibited vascular endothelial growth factor induced proliferation and tube formation in cultured human umbilical vein endothelial cells (IC50 9.9 and 6.8 uM, respectively).

References: Neuroscience. 1999; 94(4):1245-52; J Urol. 2003 Feb; 169(2):724-9.

Related CAS#: 63590-64-7 (free base); 63074-08-8 ( Terazocin Hydrochloride);