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Levobetaxolol HCl (AL-1577A)

Levobetaxolol HCl (AL-1577A)

Item no.	V1158-1g
Manufacturer	InvivoChem LLC
CASRN	116209-55-3
Amount	1 g
Quantity options	100 mg 250 mg 25 mg 2 g 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1158CAS #:116209-55-3 Purity >=98% Description: Levobetaxolol HCl ((S)-Betaxolol; AL 1577A; Betaxon; AL-1577A) is the hydrochloride salt of Levobetaxolol which is a potent beta-adrenergic receptor inhibitor /beta blocker with antihypertensive effects. Levobetaxolol is the S-isomer of betaxolol which exhibits a higher affinity at cloned human beta1 and beta2 receptors with Ki value of 0.76 nM and 32.6 nM, respectively. It is used to lower the pressure in the eye in treating conditions such as glaucoma. Levobetaxolol potently antagonizes functional activities at cloned human beta1 and beta2 receptors, respectively. Levobetaxolol (Ki = 16.4 nM) is more potent than dextrobetaxolol (Ki = 2.97 uM) at inhibiting isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells. Description: References: J Ocul Pharmacol Ther. 2001 Aug; 17(4):305-17; Exp Eye Res. 2002 Apr; 74(4):445-53. References: Related CAS#: 93221-48-8 (free base)
Molecular Weight (MW)	343.89
Formula	C18H29NO3.HCl
CAS No.	116209-55-3 (HCl salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 69 mg/mL (200.6 mM)
	Water: 69 mg/mL (200.6 mM)
	Ethanol: 69 mg/mL (200.6 mM)
Other info	Chemical Name: (S)-1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(isopropylamino)propan-2-ol hydrochloride InChi Key: CHDPSNLJFOQTRK-LMOVPXPDSA-N InChi Code: InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16; /h5-8, 14, 16-17, 19-20H, 3-4, 9-13H2, 1-2H3; 1H/t17-; /m0./s1 SMILES Code: O[CH](CNC(C)C)COC1=CC=C(CCOCC2CC2)C=C1.[H]Cl
Synonyms	AL 1577A; (S)-Betaxolol hydrochloride; AL 1577A; Levobetaxolol hydrochloride; AL-1577A; AL1577A; Betaxon

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Amount: 1 g

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