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Loratadine (Loratidine; SCH 29851)

Loratadine (Loratidine; SCH 29851)

Item no.	V1208-1g
Manufacturer	InvivoChem LLC
CASRN	79794-75-5
Amount	1 g
Quantity options	100 mg 250 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1208CAS #:79794-75-5Purity >=98% Description: Loratadine (formerly SCH29851; SCH-29851; Claritin; Loratidine; Clarityn; Alavert) is a potent and 2nd-generation histamine H1 receptor antagonist which has been approved for the treatment of allergies such as allergic rhinitis and urticaria. It also acts as a selective inhibitor of B(0)AT2 with IC50 of 4 uM. Loratadine lacks central nervous system depressing effects such as drowsiness. It has been shown to inhibit the release of leukotriene C4 and histamine from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs. Loratadine is a selective inverse peripheral histamine H1-receptor agonist. Description: References: J Med Chem. 2014 Nov 26; 57(22):9473-9; Clin Exp Allergy. 1997 May; 27(5):559-67. References: Related CAS#: 165739-83-3 (4-Chloroloratadine); 170727-59-0 (Isoloratadine); 100643-71-8 (Desloratadine); 125743-80-8 (Loratadine impurity F)
Molecular Weight (MW)	382.88
Formula	C22H23ClN2O2
CAS No.	79794-75-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 17 mg/mL (44.4 mM)
	Water: < 1 mg/mL
	Ethanol: 77 mg/mL (201.1 mM)
Solubility (In vivo)	Chemical Name: ethyl 4-(8-chloro-5, 6-dihydrobenzo[1, 2]cyclohepta[2, 4-b]pyridin-11-ylidene)piperidine-1-carboxylate InChi Key: JCCNYMKQOSZNPW-UHFFFAOYSA-N InChi Code: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4, 7-8, 11, 14H, 2, 5-6, 9-10, 12-13H2, 1H3 SMILES Code: CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Synonyms	SCH29851; Loratadine; Claritin; Loratidine; Clarityn; Alavert; Loratadine; Sch 29851; Sch-29851; Sch29851

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Amount: 1 g

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