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Description: BCI-215 is a novel, potent and selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor which has cytotoxicity for tumor cells but not normal cells.
References: Kaltenmeier CT, Vollmer LL, Vernetti LA, Caprio L, Davis K, Korotchenko VN, Day BW, Tsang M, Hulkower KI, Lotze MT, Vogt A. A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity. J Pharmacol Exp Ther. 2017 Apr; 361(1):39-50. doi: 10.1124/jpet.116.239756. Epub 2017 Feb 2. PubMed PMID: 28154014; PubMed Central PMCID: PMC5363763.
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