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Description: JNJ-7777120 (JNJ7777120; JNJ 7777120), an indole analog, is a potent and selective non-imidazole-based histamine H4R receptor antagonist that can reduce allergic and asthmatic symptoms. It inhibits histamine H4R receptor with a Ki of 4 +/-1 nM. JNJ-7777120 was identified from a HTS/high throughput screen by Johnson & Johnson Pharmaceuticals. J
References: J Med Chem. 2003 Sep 11; 46(19):3957-60; J Pharmacol Exp Ther. 2004 Apr; 309(1):404-13.
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