« Back
Home /
Nilotinib HCl hydrate

Nilotinib HCl hydrate

Item no.	V12775-250mg
Manufacturer	InvivoChem LLC
CASRN	923288-90-8
Amount	250 mg
Quantity options	100 mg 1 g 2 g 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V12775CAS #:923288-90-8Purity >=98% Description: Nilotinib HCl hydrate (formerly also known as AMN-107, AMN107 HCl hydrate) is a potent, orally bioavailable aminopyrimidine-derivative Bcr-Abl inhibitor with IC50 less than 30 nM in Murine myeloid progenitor cells. It is an FDA-approved drug for the treatment of imatinib-resistant chronic myelogenous leukemia. Nilotinib was designed based on the structure of imatinib and showed the superiority over imatinib in newly diagnosed or imatinib-resistant chronic myelogenous leukemia (CML). It was more potent than imatinib to wild-type BCR-ABL in a wide range of CML-derived and transfected cell lines. Nilotinib was also efficacious in gastrointestinal stromal tumors. Description: References: Blood. 2007; 109(5):2112-20. Epub 2006 Oct 26; J Hepatol. 2011; 55(3):612-25; Cancer Cell. 2005; 7:129-41. References: Related CAS #: 923288-90-8 (HCl hydrate) 923288-95-3(HCl) 641571-10-0 (free base)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 13 days

Compare

Add to wishlist

Get an offer