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(+)-Bicuculline

(+)-Bicuculline

Item no.	V1287-250mg
Manufacturer	InvivoChem LLC
CASRN	485-49-4
Amount	250 mg
Quantity options	100 mg 1 g 25 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1287CAS #:485-49-4Purity >=98% Description: (+)-Bicuculline (BRN-0098786; NSC-32192; BRN0098786; NSC32192), a phthalide-isoquinoline-based natural product isolated from Dicentra cucullaria, is a novel, light-sensitive and competitive antagonist of GABAA receptors with an IC50 of 2 uM. It induces clonic and tonic-clonic seizures after systemic administration. References: Pflugers Arch. 1999 Aug; 438(3):314-21; Eur J Pharmacol. 2003 Mar 7; 464(1):1-8. Related CAS: 53552-05-9 (?)-Bicuculline methochloride; 40709-69-1 (Bicuculline methiodide)
Molecular Weight (MW)	367.35
Formula	C20H17NO6
CAS No.	485-49-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 21 mg/mL (57.2 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: (R)-6-((S)-6-methyl-5, 6, 7, 8-tetrahydro-[1, 3]dioxolo[4, 5-g]isoquinolin-5-yl)-[1, 3]dioxolo[4, 5-e]isobenzofuran-8(6H)-one InChi Key: IYGYMKDQCDOMRE-ZWKOTPCHSA-N InChi Code: InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3, 6-7, 17-18H, 4-5, 8-9H2, 1H3/t17-, 18+/m0/s1 SMILES Code: O=C1O[CH]([CH]2N(C)CCC3=CC4=C(OCO4)C=C23)C5=CC=C(OCO6)C6=C51
Synonyms	d-Bicuculline; Bicculine; Bicucullin; BRN 0098786; NSC 32192; BRN0098786; NSC32192; BRN-0098786; NSC-32192

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Amount: 250 mg

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