(R)-baclofen (STX209)

Description: (R)-baclofen (formerly STX-209; STX209; STX 209), a derivative of gamma-aminobutyric acid, is a selective GABAB receptor agonist that has been primarily used to treat spasticity. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing. It acts at spinal and supraspinal sites, reducing excitatory transmission. GABAB receptors are metabotropic receptors which produce slow inhibitory signals.

References: J Neurochem. 1986 Sep; 47(3):898-903; Lancet. 1984 May 12; 1(8385):1078.

Related CAS No.: 63701-55-3 (R)-Baclofen HCl; 847353-30-4 (Arbaclofen placarbil); 69308-37-8 (Arbaclofen);