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Description: Prasugrel (formerly CS-747, PCR-4099; LY-640315; trade name Effient; Prasita), a piperazine derivative, is an irreversible and thienopyridine-based ADP receptor (P2Y12) antagonist approved as an antiplatelet and anticoagulant drug used for the reduction of thrombotic cardiovascular events. As a platelet aggregation inhibitor, it is used to prevent thrombosis in patients with acute coronary syndrome; unstable angina and myocardial infarction, as well as in those undergoing percutaneous coronary interventions. Prasugrel was also approved for use in Europe in February 2009 and On July 10, 2009 in the US for for the reduction of thrombotic cardiovascular events in patients with acute coronary syndrome who are to be managed with PCI.
References: Biochem Pharmacol. 2007; 74:1003-9; Eur J Pharmacol. 2009; 612:29-34.
Related CAS#: 389574-19-0 (HCl salt); 150322-43-3 (free base); 389574-20-3 (Prasugrel Maleic acid)
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