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A-438079 HCl

A-438079 HCl

Item no.	V1305-25mg
Manufacturer	InvivoChem LLC
CASRN	899431-18-6
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1305CAS #:899431-18-6Purity >=98% Description: A-438079 HCl (A438079; A 438079), the hydrochloride salt of -438079, is a novel, potent, and selective P2X7 receptor antagonist with anti-Parkinson's disease effects. It inhibits P2X7 receptor with a pIC50 of 6.9. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson's disease. Description: References: Neuroscience. 2007 Jun 8; 146(4):1817-28; CNS Neurosci Ther. 2014 Jun; 20(6):556-64. References: Related CAS#: 899507-36-9 (free base)
Molecular Weight (MW)	342.61
Formula	C13H10Cl3N5
CAS No.	899431-18-6 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 61 mg/mL (178.0 mM)
	Water: 61 mg/mL (178.0 mM)
	Ethanol: 20 mg/mL warmed (58.4 mM)
Solubility (In vivo)	Saline: 30mg/mL
Synonyms	A-438079; A 438079; A438079; A-438079 HCl.

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Amount: 25 mg

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