« Back
Home /
LY2886721

LY2886721

Item no.	V1312-10mg
Manufacturer	InvivoChem LLC
CASRN	1262036-50-9
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1312CAS #:1262036-50-9 Purity >=98% Description: LY2886721 (LY 2886721; LY-2886721) is a novel, potent and selective BACE (beta-secretase) inhibitor with the potential for the treatment of AD-Alzheimer's Disease. BACE1 is a key protease controlling the formation of amyloid beta, a peptide hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD). LY2886721 elicits robust central Abeta pharmacodynamic responses in mice, dogs, and humans. LY2886721 has high selectivity against key off-target proteases, which efficiently translates in vitro activity into robust in vivo amyloid beta lowering in nonclinical animal models. Description: References: J Alzheimers Dis. 2011; 24 Suppl 2:43-52; J Neurosci. 2015 Jan 21; 35(3):1199-210. References: Related CAS#: 262036-49-6 (HCl )
Molecular Weight (MW)	390.41
Formula	C18H16F2N4O2S
CAS No.	1262036-50-9 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 9 mg/mL (23.1 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: N-(3-((4aS, 7aS)-2-amino-4a, 5, 7, 7a-tetrahydro-4H-furo[3, 4-d][1, 3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide InChi Key: NIDRNVHMMDAAIK-YPMLDQLKSA-N InChi Code: InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6, 10H, 7-9H2, (H2, 21, 24)(H, 23, 25)/t10-, 18-/m0/s1 SMILES Code: O=C(NC1=CC=C(F)C([C]23N=C(N)SC[C]2([H])COC3)=C1)C4=NC=C(F)C=C4
Synonyms	LY2886721; LY-2886721; LY 2886721

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 10 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Get an offer