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LY2811376

LY2811376

Item no.	V1313-500mg
Manufacturer	InvivoChem LLC
CASRN	1194044-20-6
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1313CAS #:1194044-20-6Purity >=98% Description: LY2811376 (LY-2811376; LY 2811376) is a novel, potent, selective and the first orally bioavailable non-peptidic beta-secretase (BACE1) inhibitor with the potential for the treatment of Alzheimer's Disease (AD). It inhibits BACE1 with an IC50 of 239 nM, and is able to decrease Abeta secretion with EC50 of 300 nM. LY2811376 was identified by fragment-based screening, and was able to lower Abeta levels in a mouse model of Alzheimer's disease as well as in normal dogs. Description: References: J Neurosci. 2011 Nov 16; 31(46):16507-16; J Neurochem. 2004 Dec; 91(6):1249-59. References:
Molecular Weight (MW)	320.36
Formula	C15H14F2N4S
CAS No.	1194044-20-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 16 mg/mL (49.9 mM)
	Water: < 1 mg/mL
	Ethanol: 64 mg/mL (199.8 mM)
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	LY2811376; LY-2811376; LY 2811376.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 9/4/2025

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